• Hypertension Harmal lowers the blood pressure by direct dilatation of the blood vessels.
• It is widely used for the management of hypertension.
• Harmal seeds have been to have toxic effect on the cancer cells. In addition, it possesses antioxidant activity.
• Harmal, therefore, can be used as a novel antioxidant and anti-tumor drug in anti-cancer therapy.
• Harmal stimulates the bone formation and inhibits its resorption.
• It can therefore f P. harmala, may be useful for treatment of osteoporosis.
• Harmal lowers the heart rate (-ve chronotropic), but it increases the force of contraction of the heart muscle (+ve inotropic).
• It therefore could be used to treat tachycardia and heart failure.
• Harmal is antidepressant. Studies reveals that beta-carbolines present in Harmal strongly inhibits monoamine oxidase enzyme, and thus the degradation of serotonin and norepinephrine.
• Harmal relieves pain.
• It probably produces its analgesic effect probabaly through an opioid-modulated mechanism, and thus acts both centrally and peripherally.
• It is useful in the management of pain in various painful diseases.
• Harmal has been reported to possess anti-bacterial, anti-fungal, and anti-protozoal activity.
• It is therefore useful in various bacterial, fungal, and prpotozoal infections. sistant isolates of bacteria.
• Harmala increases menstrual flow and increases uterine contractions. It is thus used in oligomenorrhea.
• This activity results from its quinazoline alkaloids (vasicine and vasicinone). However, it should not be used during pregnancy, as it may result in abortion.

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